Stay out of this :p
Several high end/professional sound cards come in PCI form, the same for some A/V cards and tuners ( DVB-S2 for example, satellite tv on pc ).
On my main HTPC ( movies + gaming + music ) I'm using 2 PCI slots and 3 PCI-Express slots.
A new BUS/Slot more suitable for A/V than PCI-Express would be more than welcome, but can't see that happening prior to 2013.
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