[lesstutrey]

The in and out really don't matter apart from pump/block convenience in mounting (usually see res>pump>rad>block>res). The orientation of them also shouldn't really make a difference. I'd drill outside to in, the inside of the hole will be covered up with a screw/bolt head (they're #6 screws, i think 32 pitch, positive, but they are #6 for sure). And maybe i need to read the thread better but how are the hoses getting in?

Orientation of in and out as well as the angle doesn't matter because the loop will just hit it's t-delta and it won't really matter. The whole rad will be roughly the same temp so just use the in and our that is convenient for your situation. No certain mount orientation will provide you with better results, so if you like the angle thing, go with it.